Loss of IGF-IEa or IGF-IEb Impairs Myogenic Differentiation
نویسندگان
چکیده
منابع مشابه
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration.
The discovery that IGF-I mRNAs encoding isoforms of the pro-IGF-I molecule are differentially regulated in response to mechanical stress in skeletal muscle has been the impetus for a number of studies designed to demonstrate that alternative splicing of IGF-I pre-mRNA involving exons 4, 5, and 6 gives rise to a unique peptide derived from pro-IGF-I that plays a novel role in myoblast proliferat...
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We have studied the expression of insulin-like growth fador type II (IGF-ll) and its autocrine role during the proliferation and differentiation of the CaCo-2 colon carcinoma cell line. ICE-Il RNA levels were high in proliferating cells and decreased by more than 10-fold when cells ceased to proliferate and differentiated. Immunoreadive ICE-Il protein was high in the conditioned media of prolif...
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IN 1998, ROSENFELD AND OH (9) likened insulin-like growth factors (IGFs) in endocrinology to the elephant in the parable of the blind men and the elephant. Since then, IGFs, and especially IGF-I, may have well become the elephant in other disciplines as well due to the numerous effects IGFs can exert in different tissues and cells. IGF-I is a pleiotropic peptide with tissueand cellspecific effe...
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Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are interested in the role of insulin-like growth factor-I (IGF-I) in SC development. We have shown previously SCs proliferate in response to IGF-I in vitro. In the current study...
متن کاملInhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation.
Mitochondria are dynamic organelles forming a tubular network that is continuously fusing and dividing to control their morphology and functions. Recent literature has shed new light on a potential link between the dynamic behavior of mitochondria and muscle development. In this study, we investigate the role of mitochondrial fission factor dynamin-related protein 1 (Drp1) in myogenic different...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2011
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2010-1279